Basophilic stippling

Basophilic stippling aka Punctate basophilia refers to an observation found when observing a blood smear, where erythrocytes display small dots at the periphery. These dots represent accumulations of rRNA and are always pathological.[1]

It is associated with several conditions, including:

See also

References

  1. ^ http://diaglab.vet.cornell.edu/clinpath/modules/rbcmorph/bse.htm
  2. ^ "Pathology". http://www.med-ed.virginia.edu/courses/path/innes/rcd/side.cfm. Retrieved 2009-02-08. 
  3. ^ Valentine WN, Paglia DE, Fink K, Madokoro G (October 1976). "Lead poisoning: association with hemolytic anemia, basophilic stippling, erythrocyte pyrimidine 5'-nucleotidase deficiency, and intraerythrocytic accumulation of pyrimidines". J. Clin. Invest. 58 (4): 926–32. doi:10.1172/JCI108545. PMC 333255. PMID 965496. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=333255. 
  4. ^ Harrington AM, Ward PC, Kroft SH (March 2008). "Iron deficiency anemia, beta-thalassemia minor, and anemia of chronic disease: a morphologic reappraisal". Am. J. Clin. Pathol. 129 (3): 466–71. doi:10.1309/LY7YLUPE7551JYBG. PMID 18285271. http://ajcp.metapress.com/openurl.asp?genre=article&id=doi:10.1309/LY7YLUPE7551JYBG. 
Abnormal clinical and laboratory findings for blood tests (R70–R79, 790)
Red blood cells
Size
Shape (Poikilocyte)
membrane abnormalities: Acanthocyte · Codocyte · Ovalocyte · Spherocyte
developmental organelles (Howell-Jolly body, Basophilic stippling, Pappenheimer bodies, Cabot rings)
abnormal hemoglobin precipitation (Heinz body)
Other
Lymphocytes
Small molecules
Nitrogenous
Proteins
Other
Minerals
Pathogens/sepsis

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

M: URI

anat/phys/devp/cell

noco/acba/cong/tumr, sysi/epon, urte

proc/itvp, drug (G4B), blte, urte